Regulating inflammation: ADAM8 - a new player in the game
نویسندگان
چکیده
منابع مشابه
Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game
The interaction between tumor progression and innate immune system has been well established in the last years. Indeed, several lines of clinical evidence indicate that immune cells such as tumor-associated macrophages (TAMs) interact with tumor cells, favoring growth, angiogenesis, and metastasis of a variety of cancers. In most tumors, TAMs show properties of an alternative polarization pheno...
متن کاملFSAP, a new player in inflammation?
Factor VII-activating protease (FSAP) is a serine protease in plasma that has a role in coagulation and fibrinolysis. FVII could be activated by purified FSAP in a tissue factor independent manner and pro-urokinase has been demonstrated to be a substrate for purified FSAP in-vitro. However, the physiological role of FSAP in haemostasis remains unclear. More recently FSAP is suggested to be invo...
متن کاملIvermectin: A New Player in the Rosacea Game
I n the most recent issue of this publication, we provided an overview of current classifications and grading systems that define rosacea, along with information on traditional therapeutic approaches for the management of inflammatory papules and pustules. In this issue, we’ll focus on ivermectin 1%, the newest addition to the rosacea armamentarium, by reviewing its mechanism of action and expl...
متن کاملThe mitochondrial citrate carrier: a new player in inflammation.
The mitochondrial CIC (citrate carrier) catalyses the efflux of citrate from the mitochondrial matrix in exchange for cytosolic malate. In the present paper we show that CIC mRNA and protein markedly increase in lipopolysaccharide-activated immune cells. Moreover, CIC gene silencing and CIC activity inhibition significantly reduce production of NO, reactive oxygen species and prostaglandins. Th...
متن کاملSR-BI: a new player in an old game.
Monocyte-derived macrophages are among the first cells to accumulate in atherosclerotic lesions. Primarily, they appear to scavenge lipids and lipoproteins from fatty streaks, but their long-term presence and accumulation of cholesterol and cholesteryl esters is the hallmark of atherosclerosis. Atherogenesis begins by a perturbation in the endothelium. Subsequently, blood monocytes and later T ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2011
ISSN: 0014-2980
DOI: 10.1002/eji.201142196